HMG is possibly superior to recombinant FSH for IVF

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Highly purified HMG versus recombinant FSH for ovarian stimulation in IVF cycles.

The objective of this study was to compare the live birth rates resulting from ovarian stimulation with highly purified human menopausal gonadotrophin (HP-HMG), which combines FSH and human chorionic gonadotrophin-driven LH activities, or recombinant FSH (rFSH) alone in women undergoing IVF cycles. An integrated analysis was performed of the raw data from two randomized controlled trials that w...

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Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients.

BACKGROUND Highly purified menotrophin (HP-hMG) has been associated with fewer oocytes retrieved and a higher proportion of top-quality embryos compared with recombinant FSH (rFSH). METHODS A randomized, assessor-blind, multinational trial in 731 women undergoing IVF after stimulation with HP-hMG (MENOPUR) (n = 363) or rFSH (GONAL-F) (n = 368) following a long GnRH agonist protocol was conduc...

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Recombinant FSH versus HP-HMG for controled ovarian stimulation in intracitoplasmic sperm injection cycles.

UNLABELLED The aim of this study was to make a conclusion about aplicability of two differnet gonadothropins in COS (rFSH versus HP-hMG). The primary conclusion for the success as a result of COS are the mean number of retrived oocytes, mature oocytes, fertilization rate, mean number of quality embrios, and criopreverzed embrios. The secondary conclusions were clinical pregnancy rate and delive...

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Meta-analysis of recombinant FSH and urinary-derived gonadotrophins for IVF or ICSI.

Di Simone, N., Ferrazzani, S., Castellani, R., De Carolis, S., Manscuso, S. and Caruso, A. (1997) Heparin and low dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibodycontaining sera. Hum. Reprod., 12, 2061±2065. Di Simone, N., Meroni, P.L., del Papa, N., Raschi, E., Caliandro, D., De Carolis, C.S., Khamashta, M.A., Atsumi, T., Hughes, G.R...

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Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists--a randomized study.

BACKGROUND Highly purified hMG (hp-hMG) has recently shown better cycle outcome than the recombinant FSH (rFSH) when compared in GnRH agonist long protocol cycles. However, they have not yet been compared in GnRH antagonist cycles. METHODS A RCT comparing the ongoing pregnancy rate (primary end-point) in 280 patients undergoing IVF/ICSI after stimulation with hp-hMG or rFSH controlled with a ...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2001

ISSN: 1460-2350,0268-1161

DOI: 10.1093/humrep/16.11.2473